Design Development and Solubility Enhancement of BCS Class II Drug For The Treatment of Prostate Cancer Using Solid Dispersion Technique

Abstract

Solid dispersion has become a well-established solubilization method for weakly water-soluble medications. In this, we are dealing with an antineoplastic drug that belongs to BCS class II used for treating prostate cancer to enhance the solubility of a particular drug we prefer solid dispersion. The creation of solid dispersions as a feasible way of increasing the bioavailability of poorly water-soluble pharmaceuticals overcame the constraints of previous efforts including salt production, cosolvent solubilization, and particle size reduction. The drug-polymer interaction is the defining factor in the design and performance of a solid dispersion since it is essentially a two-component drug-polymer system. Solid Dispersion is prepared by various methods and it is more cost-effective and efficient compared to conventional dosage forms. Various trials were taken using various techniques such as hot-melt extrusion, top spray granulation, solvent evaporation, and spray drying and by changing various polymers at the end, we go with the Spray drying method and use Hydroxyethylcellulose for changing the Crystalline form of the drug into its amorphous form. So, it can conclude that using the spray drying method and Hydroxyethylcellulose we can prepare an IR tablet that is pharmaceutical equivalent to the reference product and stable as compared to another formulation.