Development and Formulation of Delayed ReleaseTablets of an Antifungal Agent

Abstract

Solubility is a very important factor for the proper dissolution of the drug which ultimately leads to have proper bioavailability. If the drug is having poor solubility, the bioavailability of the drug will be low. The major problem for the formulation is drugs having low aqueous solubility which leads to poor bioavailability of the drug. The poorly soluble drugs then need higher doses to reach to the therapeutic level. There are various techniques available for solubility enhancement such as micronization, salt formation, complexation, surfactant addition and solid dispersion. The BCS have done classification on the basis of solubility and permeability of drug. In this experiment solubility enhancement of BCS Class II drug has been done having low solubility and high permeability. From the different techniques of solubility enhancement three techniques were used from physical modification such as micronization in which the particle size of the drug is being reduced with the help of communition or milling which will help to increase particle size of the drug increasing solubility, miscellaneous techniques like surfactant addition in which the wettability of the drug is increased to improve the solubility of the drug and solid dispersion using solvent evaporation method in which there is linkage of drug and polymer which increases the solubility of the drug. The Drug-X is an antifungal agent which is available in form of delayed release tablets to overcome the disadvantages of the suspension formulation which is available in market. The delayed release tablets will give drug release at the upper intestine and prevent the release at the stomach. The aim is to improve the solubility of the drug and to prepare a formulation equivalent to the reference listed drug.