The Clinical Manifestations of Polycystic Ovarian Syndrome in Women and its Association with Various Risk Factors

Abstract

BACKGROUND: Polycystic ovarian syndrome is a gynecological disorder in which hormonal imbalances occurred and is characterized by chronic anovulation, clinical and biochemical hyperandrogenesim. OBJECTIVES: Aim of present study is to determine age wise prevalence, clinical characteristics of PCOS in woman of reproductive age in Ahmedabad region and determination of associated risk factors in development of PCOS was carried out. METHODOLOGY: A cross-sectional study was conducted among women between the age of 20-45 years. A total 150 women who visited the two hospitals were enrolled in the study. IEC was given approval. If menstrual dysfunction and clinical hyperandrogenesim were recognized in females accordance with rotterdam criteria, diagnosed as PCOS. We have unwavering amalgamation of obesity and overweight, physical activity, socioeconomic status (SES), and other risk factors with PCOS using pre-designed and pre-tested questionnaire. RESULT: Out of 150 women, 123 (82.00%) women were diagnosed as PCOS according to the Rotterdam criteria. The mean age of first menarche was found to be 13.79± 1.37in PCOS women. The highest prevalence of PCOS was found at age group of 30-34 yr. (63.33%). The significant correlation was found between hirsutism and acne with PCOS (P ≤ 0.05).In our study, the prevalence of obesity in PCOS women (63.33%) was found to be higher than non PCOS women (4.00%). We cannot able to identified relation between PCOS with blood pressure in our study. After comparison of the family medical history of PCOS females, we enfound that higher percentage of women with family history of diabetes mellitus (64.0%) were diagnosed as PCOS. PCOS women are having highest percentage of dysmenorrhea (44.67%).The levels of prolactin were increased but not found statistically significant with PCOS in our study. Among PCOS women, higher percentage belong to upper socioeconomic class (66.00%) as compared to non PCOS women (8.67%).In our study, higher percentage of PCOS women are having less physical activities were found as compared to non-PCOS women. CONCLUSION: In conclusion, we found that the higher prevalence of PCOS observed at the age between 30-34 years. The menstrual irregularity, hirsutism, dysmenorrhea and acne were clinical characteristics of PCOS. Obesity, physical inactivity and the family medical history of diabetes mellitus were observed to be significantly associated risk factors with PCOS