Please use this identifier to cite or link to this item: http://10.1.7.192:80/jspui/handle/123456789/12125
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dc.contributor.authorHalder, Tripti-
dc.contributor.authorSaha, Bijit-
dc.contributor.authorDhas, Namdev-
dc.contributor.authorAcharya, Sanjeev-
dc.contributor.authorAcharya, Niyati-
dc.date.accessioned2024-03-30T06:41:15Z-
dc.date.available2024-03-30T06:41:15Z-
dc.date.issued2024-
dc.identifier.urihttp://10.1.7.192:80/jspui/handle/123456789/12125-
dc.description.abstractSialic acid (SA) serves a critical role in neuronal repair and cognitive functions. SA is a nine‐carbon carboxylated sugar with a glycoconjugate cap that acts as a ligand and surface decoration with SA facilitates delivery to the target site. The present research aimed to develop SA surface modified AA nanostructured lipid carrier (NLCs) with carbodiimide conjugation method. Sterylamine, poloxamer 188 and tween 80 were used as surfactants and several characterization studies including, differential scanning calorimetry, fourier transform infrared spectroscopy and x‐ray photon spectroscopy were analyzed. Further, in vitro, neuroprotective efficiency was evaluated in SH‐SY5Y cells and hCMEC/D3 cells and found significant potential effects with the treatments of developed NLCs. Pharmacodynamics studies were also assessed in beta‐amyloid‐injected rats following quantification of Alzheimer's disease (AD) hallmarks like, Aβ(1–42), tau‐protein, glycogen synthase kinase‐3β levels, interleukin‐6 and tumor necrosis factor‐α for neuroinflammatory responses. Characterization studies revealed the conjugation on developed NLCs. The in vitro and in vivo results showed significant effects of SA decorated NLCs in reversing the damage by toxicant which was further characterized by the levels of neurotrans mitters like acetylcholinesterase, butyrylcholinesterase. The results revealed signifi cant (p < .05) refurbishment of cholinergic functions after 28 days of treatment of developed NLCs. These preclinical findings support the use of SA as a ligand to deliver the AA at targeted site as well as to mitigate the cognitive deficits in AD.en_US
dc.publisherWiley Periodicals LLCen_US
dc.relation.ispartofseriesIPFP0531;-
dc.subjectasiatic aciden_US
dc.subjectglial fibrillary acidic proteinen_US
dc.subjectsialic aciden_US
dc.subjectstearylamineen_US
dc.subjectthioflavinen_US
dc.titleDevelopment and Evaluation of Multi-Functionalized Sialic Acid Conjugated Asiatic Acid Nanoconstruct to Mitigate Cognitive Deficits In Alzheimer'S Diseaseen_US
dc.typeFaculty Papersen_US
Appears in Collections:Faculty Papers

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