Conventional and Microwave Assisted Degradation Study of Drug-Excipients Using High-Performance Liquid Chromatography and Microwave-Assisted Degradation Study of Drug-Excipients Using High-Performance Thin Layer Chromatography

Abstract

MAJOR PROJECT: ABSTRACT This study aims to examine the breakdown of two commonly used drugs, Promethazine Hydrochloride (PMZ) and Hydrochlorothiazide (HTZ), using both traditional and microwave degradation methods. The stability of these drugs under various degradation conditions is crucial to maintain their effectiveness and safety. The study employs advanced analytical techniques, such as high-performance liquid chromatography (HPLC), to observe and analyze the degradation of PMZ and HTZ. To compare the impact of the energy source on drug stability, microwave-assisted degradation is evaluated against traditional degradation techniques. The results reveal that microwave degradation produces unique patterns of degradation products and reaction kinetics in comparison to conventional methods. The differences in degradation pathways and reaction rates underscore the influence of energy sources on drug stability. MINOR PROJECT: ABSTRACT This research examines the degradation of Promethazine Hydrochloride (PMZ) and Hydrochlorothiazide (HCTZ) using microwave methods. Employing high-performance thin- layer chromatography (HPTLC), the study tracks how these drugs break down under microwave conditions, known for their rapid and effective reactions. Results indicate that microwave degradation produces unique degradation products and reaction kinetics compared to traditional methods, highlighting the influence of energy sources on drug stability. Understanding these differences helps optimize drug formulation and storage, ensuring quality and effectiveness throughout their shelf life, and contributes to the broader pharmaceutical sciences by enhancing knowledge of drug stability and degradation mechanisms.