Evaluate the effect following co-administration of Streptozotocin with High-Sucrose Fructose Diet on Fatty Acids Derivatives and Liver Pathophysiology

Abstract

Metabolic disorders are one of the -major concerned diseases worldwide. High sucrose fructose diet plays a major role in altering metabolism. When we talk about metabolic diseases like non- alcoholic fatty liver disease, non-alcoholic steatohepatitis, and Type 2 Diabetes. High sucrose fructose diet is one of the inducers of it. Reported data suggest, streptozotocin is being used to induce disorder like diabetes mainly type 1. In our study we wanted to analyse the morphological, biochemical and expression parameters in the animals fed with high sucrose fructose diet and high sucrose fructose diet along with different doses of streptozotocin for different duration of time period so the animals were divided in four different groups. Normal control, high sucrose fructose diet for 90 days, high sucrose fructose diet for 90 days along with mixed dose of streptozotocin and high sucrose fructose diet for 30 days and high dose of streptozotocin. And from our studies we found nearly significant results. The effect of high sucrose fructose diet and streptozotocin on the gut microbiota and their metabolites. As we know that in any metabolic disorder especially type 2 diabetes and inflammatory disease, gut microbiome alters. The population of gram-positive bacteria and gram-negative bacteria are concerned for the regulation of it or to prevent or induce disease condition. In-addition to this when we talk about the high sucrose fructose diet and gut microbiota, fatty acid derivatives also play a significant role. These fatty acid derivatives were also analysed using HPLC and the results came out to nearly relevant.