Emerging Trends in Development of Multivariate Models in Solid Dosage Forms: A Review

Abstract

In the formulation and manufacture of pharmaceuticals, the creation is pursued in the application of multivariate modelling methods designed with the creation of these intricate solid dosage forms in mind. The paper investigates a range of multivariate modelling techniques for predicting dissolution profiles and optimising formulation compositions, such as factorial and mixed designs. It also looks at more contemporary developments, such as the incorporation of artificial intelligence to improve predictive modelling and optimise production procedures. It demonstrates the usefulness and practical use of these strategies through case studies. In the end, the review emphasises how important multivariate modelling is for improving pharmaceutical production methods and handling formulation difficulties. Multi-layer tablets—especially bi- and tri-layer tablets—presents special potential and challenges. This review delves into the new directions being.