Novel Approahces Used in Transdermal Drug Delivery Systems

Abstract

Transdermal drug delivery systems have generated widespread interest due to its ability to provide non-invasive, patient-friendly methods for drug administration. This presentation discusses current advances in TDDS, with a particular focus on novel techniques that incorporate microneedle technology, hydrogel nanoparticles, and synergistic drug combinations. Microneedle-based systems have developed as highly effective techniques for improving medication delivery across the epidermal barrier. Microneedles make microchannels in the the dermis, allowing medications to penetrate and overcome the stratum corneum's barrier qualities. Recent advances in microneedle fabrication techniques, such as dissolvable and hollow microneedles , have increased medication delivery efficiency and patient comfort. Hydrogel nanoparticles are another promising option for transdermal medication delivery. These nanocarriers have high drug loading capacity, prolonged release patterns, and programmable characteristics that improve skin permeability. Incorporating pharmaceuticals into hydrogel nanoparticles additionally shields them from degradation, but also allows for regulated release kinetics, which extends the therapeutic window. Combinational systems that incorporate various drug delivery technologies provide synergistic benefits in transdermal medication administration. Researchers found that combining microneedle arrays with hydrogel nanoparticles improved drug penetration, delayed release, and targeted delivery to certain skin layers or cell types. Furthermore, the capacity to co- deliver numerous medications or therapeutic agents allows for customised treatment regimens for complex medical problems. Looking forward, the integration of microneedle hydrogel nanoparticles with combinational systems has enormous potential for improving transdermal drug delivery. These novel techniques present prospects to overcome the drawbacks of classic TDDS, such as limited drug penetration and low patient compliance.