Evaluation of the Effect of Combination of Extracts of Acorus calamus and Semecarpus anacardium in Chronic Pseudomonas aeruginosa Lung Infection in Rats

Abstract

P. aeruginosa is responsible for severe chronic infections in patients which suffer from chronic lung diseases. Current therapies for treatment infections include dual antibiotic therapies. However P. aeruginosa has developed resistance to many of these antibiotics and the microenvironment of the lung in these patients and various survival strategies of this pathogen decrease the affectivity of the antibiotics which has resulted in urgent need for new therapeutics and new approaches for treatment. In this study effect of mixture of extracts of A. calamus and S. anacardium were studied on chronic P. aeruginosa lung infections in rats. Results show eradication of bacteria from lungs of rats, decreased inflammation and oxidative stress and recovery of lung function marked by initiation of regeneration of alveolar walls.