Formulation Design and Optimization of topical Microemulsion in Situ Gelling System: Drug Delivery to Posterior Segment of the Eye

Abstract

The purpose of this research was to develop the microemulsion based in situ gelling system of gatifloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Gatifloxacin is well reported for the treatment of endophthalmitis, it has better penetration into ocular tissues and high potency compared to many of the same class drugs. Unlike halogenated fluoroquinolones it is safe to use in higher dose and is devoid of phototoxicity. So, Gatifloxacin was used as a model drug. Formulation approach provides better absorption, penetration, retention and improves bioavailability of the drug. The average conc. reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 μg/ml, which is far more than concentration required for therapeutic effect (i.e. >0.1 μg/ml or > >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Thus, novel microemulsion based in situ gelling formulation could be potential drug delivery system for treatment of posterior segment diseases like endophthalmitis.