Synthesis and Antimicrobial Activity of Novel Pyrazolo [3,4-d] Pyrimidine Derivatives

Abstract

A series of new N-(2,5-dimethylphenyl)-7-methyl/7-methyl -3-oxo-5-phenyl-2,3-dihydro-5H-[1,3]thiazolo[3,2-a] pyrimidine-6-carboxamide have been synthesized by a three component (MCR) reaction involving N-(2,5-dimethylphenyl)-3-oxobutanamide,thioura and substituted benzaldehyde gives N-(2,5- dimethylphenyl)-6-methyl-4-phenyl-2-sulfanyl-1,2,3,4-tetrahydro pyrimidine-5-carboxamide which on reaction with dibromoethane /chloro acetylchloride respectively. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi. The results of such studies have been discussed in this paper.