Synthesis and Pharmacological Evaluation of Substituted Dihydropyrimidine Derivatives as an Antihypertensive Agent

Abstract

Hypertension is a worldwide diseases caused by several environmental factor as well as genetic factor. Some pyrimidine analogs were synthesized to be evaluated for their antihypertensive effect in animal experiments. Substituted Dihydropyrimidine ring is synthesized by a simple efficient procedure, the Biginelli Reaction. A series of acetoacetanilide synthesized by aniline derivative condensed with ethaylacetoacetate in presence of base. Acetoacetanilide was condensed with urea and aromatic aldehyde in ethanolic medium to give substituted dihydropyrimidine. The structure of synthesized compounds has been confirmed on the basis of their spectral (IR, Mass and NMR) data. The purity of the compounds was confirmed by TLC. All these compounds were evaluated for their in vitro activity in rat uterus smooth muscle by Drug Response Curve method. Compound MJV-A26M4, MJV-A4N3, MJV-A4N4, MJV-A26D34 exhibited good antihypertensive activity against Calcium channel with the reference standard Nifedipine.