Synthesis and Pharmacololgical Evaluataion of substituted Styral Benzimidazole Derivattives

Abstract

(E)-4-chloro-N-((2-(4-nitrostyryl)-1H-benzo[d]imidazol-1-yl) methyl) aniline analogs (SV – 1 to SV - 13) were synthesized from 2-styryl benzimidazole [27] and substituted phenyl amine derivatives in presence of DMF and formaldehyde. 2-styryl benzimidazoles [27] have been synthesized from 2-methyl benzimidazole through the condensation reaction with various aromatic aldehydes. The structure of synthesize compounds has been established on the basis of their spectral data (IR, 1H NMR and Mass). The purity of the compounds was confirmed by TLC. The synthesized compounds were evaluated for antibacterial activity against several bacteria using cup plate method. Compounds SV-3, SV-4, SV-7, SV-9 and SV-13 were exhibited good antibacterial activity against E. coli, B. subtilis, S. aureus and K. pneumonia and comparable with standard streptomycin.