Shah NN, Shah TJ, Amin AF

Please use this identifier to cite or link to this item: http://10.1.7.192:80/jspui/handle/123456789/3140

Title:	Shah NN, Shah TJ, Amin AF
Other Titles:	In-Vitro Evaluation Of Pectin As A Compression Coating Material For Colon Targeted Drug Delivery
Authors:	Shah, Nitesh Shah, Tejal A. Amin, Avani F.
Keywords:	Crohn’s Disease Degree of esterification HP-β-CD, HPMC swelling study Facuty Paper Pharmacy Faculty Paper
Issue Date:	2011
Publisher:	Elsevier
Series/Report no.:	IPFP0049
Abstract:	Colon targeted delivery of satranidazole (STZ), which immediately releases the drug as soon as the drug delivery system reaches the colon was formulated. Different grades of pectin were used as a compression coat and the effect of degree of esterification (DE) of pectin on swelling and drug release property was evaluated. STZ is a sparingly soluble drug, so to obtain maximum effect of drug at the site of action the solubility enhancement was carried out using Hydroxypropyl-β-cyclodextrin (HP-β-CD). Pectin as a compression coat was unable to direct STZ containing core tablets to the colon, so HPMC was added to increase the tensile strength of the coat. STZ core tablets compression coated with High DE pectin: HPMC in 1:1 ratio imparted the lag time of 5 h and burst release in colon.
Description:	International Journal of Pharma and Bio Sciences. 2(2), 2011
URI:	http://10.1.7.181:1900/jspui/123456789/3140
ISSN:	0975-6299
Appears in Collections:	Faculty Papers

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