Synthesis of Chalcone Derivatives of Coumarin and 2-amino Bezothiazole as Antioxidants

Abstract

Oxidation is a chain of chemical reactions generating free radicals by transferring electrons from a substrate to an oxidizing agent. Oxygen is a highly reactive molecule that damages living organisms by producing free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS). An excess of these free radicals leads to diseases like aging, diabetes, cancer, atherosclerosis, Parkinson’s disease, Alzheimer, inflammation, etc. An antioxidant is a molecule capable of inhibiting the oxidation of other molecules by maintaining the balance between the processes generating and utilizing the free radicals. Literature survey revealed that more than 1300 coumarins have been identified from natural sources and they exhibited good antioxidant activity. Also natural antioxidants like curcumin and resveratrol contain stilbene moiety giving antioxidant activity. Extensive survey also revealed that 2-amino benzothiazole moiety shows better antioxidant activity. Hence two series of compounds were designed and synthesized as potential antioxidants. Structure elucidation of the synthesized compounds was done by spectral analysis. The antioxidant activity of the synthesized compounds was determined by Nitric oxide, Superoxide, DPPH and Hydrogen peroxide radical scavenging activity using ascorbic acid as the reference standard.