Phytopharmacological evaluation of the bark of Symplocos racemosa Roxb. for its anti diabetic activity

Abstract

The phytochemical and pharmacological evaluation of Symplocos racemosa was carried out for its anti diabetic activity. The present study investigates the anti diabetic activities of methanolic and petroleum ether extract of S. racemosa bark in streptozotocin (STZ) induced diabetic rats. The preliminary phytochemical screening of methanolic extract showed the presence of glycosides, flavonoids, tannins, phenols, carbohydrate, alkaloids. The preliminary phytochemical screening of petroleum ether extract showed the presence of phytosterol and triterpenoids. Two doses of methanolic extract (150 and 300 mg/kg) and single dose of petroleum ether extract (100 mg/kg) of bark of S. racemosa was administered orally and compared with the standard drug Glibenclamide (0.4 mg/kg). The methanolic extract at the dose of 150 mg/kg showed potent anti diabetic activity. The petroleum ether extract at the dose of 100 mg/kg also showed potent effect. The results of the methanolic extract of the bark of Symplocos racemosa showed more potent anti diabetic activity against streptozotocin induces diabetic rats.