Antihyperlipidemic Activity of Various Combinations of Rice Bran Oil and Safflower Oil on Triton WR– 1339 Induced Hyperlipidemia in Rats

Abstract

Numerous studies investigating the effect of rice bran oil (RBO) on lipid metabolism and oxidation in rats have given interesting but often contrasting results. Therefore, the current study was initiated to investigate the anti-hyperlipidemic potential of the various combinations of safflower oil (SO), a polyunsaturated fatty acid (PUFA) rich vegetable oil and RBO in Triton WR-1339-induced acute hyperlipidemia in wistar rats. Various combinations of RBO and SO were evaluated for anti-hyperlipidemic activity by estimating serum triacylglyceride (TG), total cholesterol (TC), very low density lipoprotein-cholesterol (VLDL), low-density lipoproteincholesterol (LDL) and high-density lipoprotein-cholesterol (HDL) levels with atorvastatin as the reference standard. The degree of protection was also assessed by measuring the levels of various hepatic anti-oxidant enzymes. Administration of [RBO+SO (7:3)] for 30 days demonstrated the maximum depression in the TG and VLDL levels and the maximum elevation in HDL and HDL/ TC ratio along with a significant increase in the level of hepatic anti-oxidant enzymes. The findings indicate that [RBO+SO (7:3)] possesses the potential to lower plasma lipid concentrations and might be of therapeutic benefit in the treatment of hyperlipidemia. However further studies are warranted to confirm its mechanisms for the higher anti-hyperlipidemic effect as compared to the other combinations.