Synthesis and Pharmacological Evaluation of 4- Sulfonamido Containing Coumarin as an Antiinflammatory Agent

Abstract

First Ethyl 4-bromo acetoacetate synthesized by the bromination reaction. In the second step by using the Ethyl 4-bromo acetoacetate and substituted hydroxyl benzene different substituted 4- bromomethyl Coumarin derivatives prepared by pechmann reaction. In the final step using the 4-bromo methyl substituted Coumarin derivatives and different sulphonamide coupled to synthesize 4-sulfonamido containing substituted coumarin derivatives. Docking study of the synthesized compounds performed by using software SYBYL X 1.3 using surflex DOCK Module. Docking study of synthesized compounds performed on selective COX-2 protein (PDB ID-3NT1). All the synthesized compounds were evaluated for anti-inflammatory activity. The structure elucidation of the synthesized compound was carried out by the IR, MASS and Proton NMR. Most of the compound shows the significant anti-inflammatory activity. Comparing to the Pharmacological activity and docking results, we conclude that 4- sulfonamido containing substituted Coumarin derivatives seem to be potentially active drug.