IR @ Nirma University
Keeping in tune the global developments we are creating an institutional repository using DSpace Software (Digital Library Software). We are archiving institutional knowledge like, faculty papers, theses, and dissertations in PDF format at DSpace. Students can access this digital information anywhere in the campus.
Please use this identifier to cite or link to this item:
http://10.1.7.192:80/jspui/handle/123456789/5316| Title: | Clerodendrum serratum (L.) Moon. – A review on traditional uses, phytochemistry and pharmacological activities |
| Authors: | Patel, Jagruti Acharya, Niyati |
| Keywords: | Bharangi Saponins Clerodendrum serratum Antiasthmatic agent |
| Issue Date: | 2014 |
| Publisher: | Elsevier |
| Series/Report no.: | IPFP0124; |
| Abstract: | Ethnopharmacological relevance:Clerodendrumserratum (L.) Moon.(Verbenaceae)isanimportant medicinal plantgrowinginthetropicalandwarmtemperateregionslikeAfrica,SouthernAsia;Malaysia and distributedthroughoutinforestsofIndiaandSriLanka.Itistraditionallyvaluedandreportedfor treating pain,inflammation, rheumatism,respiratorydisorders,feverandmalarialfeverinIndiawith a longhistory.Toprovideacomprehensiveoverviewofthetraditionalandethnomedicinaluses, phytochemistryandbiologicalactivitiesof C. serratum with clinicalandtoxicitydataandpossiblymake recommendations forfurtherresearch. Materials andmethods: All relevantworldwideaccepteddatabasesweresearchedfortheterms “Clerodendrum”, “Clerodendrumserratum”, “Bharangi” and “Cheruthekku” along withtheotherliterature from Indianclassicaltextsandpharmacopoeias.Therewasnospecific timelinesetforthesearch.The accessible literaturesavailableon C. serratum werecollectedviaelectronicsearchusingPubmed,Scopus, Science Directandtraditionalbooksreportsonethnopharmacologyandtraditionalmedicines. Results: C.serratum has playedanimportantroleinIndiansystemofmedicine.Inadditiontothe common localuseinrespiratorydiseases,otherethnomedicinalusesincludetreatmentofpain, inflammation, rheumatismandfeverespeciallymalarialfever.Scientific studiesonextractsand formulations revealedanti-asthmatic,mastcellstabilizationandanti-allergiceffectsofrootsof C. serratum. Reporteddataonpharmacologicalactivitiesalsoincludeshepatoprotective,anti-oxidant, anti-inflammatory andanticancerpotentialofthedrug.Saponins(terpenoidsandsteroids), flavonoids and phenolicsisolatedfromrootshavebeenthefocusofphytochemicalinvestigationsasthebiological activity hasbeenascribedtothesaponins,whichareknowntopossessanti-inflammatoryandanti- cancer activity.Isolatedbioactivesfromrootslikeicosahydropicenicacidandursolicacidhavebeen claimed toofferanti-allergicandhepatoprotectiveactivity. Conclusions: Therapeuticpotentialofrootsandleavesof C. serratum has beendemonstratedinthe conditions likeasthma,allergy,fever,inflammation andliverdisordersattributedtothepresenceof various flavonoids,phenolicsandsaponinspresentinthedrug.Manyethnobotanicalclaimshavebeen confirmed throughmodern in-vitro and in-vivo pharmacological studiesofdifferentextractsandisolates from plant;however,additionalstudiesonthebiomarkersareneededtoestablishmechanismofaction and tovalidatethetraditionaluseofthisdruginclinicalpracticesafterpropersafetyassessment. Pharmacological activities |
| Description: | Journal of Ethnopharmacology, 154, Issue 2 , 268-285 |
| URI: | http://hdl.handle.net/123456789/5316 |
| Appears in Collections: | Faculty Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0124.pdf | IPFP0124 | 1.63 MB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.