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http://10.1.7.192:80/jspui/handle/123456789/5321Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Raghunathan, Suchi | - |
| dc.date.accessioned | 2015-01-21T09:19:31Z | - |
| dc.date.available | 2015-01-21T09:19:31Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/5321 | - |
| dc.description | European Journal of Pharmacology 728 (2014) 128–134 | en_US |
| dc.description.abstract | Wehaveevaluatedtheeffectofmagnesiumvalproate(210mg/kg/day,p.o.)intype2diabetesinduced cardiovascularcomplicationsinducedbystreptozotocin(STZ,90mg/kg,i.p.)inneonatalwistarrats.Various biochemical,cardiovascularandhemodynamicparametersweremeasuredattheendof8weeksof treatment.STZproducedsignificanthyperglycaemia,hypoinsulinemiaanddyslipidemia,whichwas preventedbymagnesiumvalproatetreatment.STZproducedincreaseinCreatinineKinase,C-reactive proteinandlactatedehydrogenaselevelsandtreatmentwithmagnesiumvalproateproducedreductionin these levels.STZproducedincreaseincardiacandLVhypertrophyindex,LV/RVratio,LVcollagendeposition andLVcardiomyocytediameterwhichweredecreasedbymagnesiumvalproatetreatment.Magnesium valproatealsopreventedSTZinducedhemodynamicalterationsandoxidativestress.Theseresultswere further supportedbyhistopathologicalstudiesinwhichmagnesiumvalproateshowedmarkedreductionin fibrosisandcardiac fiber disarray.Inconclusion,ourdatasuggeststhatmagnesiumvalproateisbeneficial as ananti-diabeticagentintype-2diabetesmellitusandalsopreventsitscardiaccomplications. | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | IPFP0129; | - |
| dc.subject | IPFP0129 | en_US |
| dc.subject | hyperglycaemia | en_US |
| dc.title | Cardioprotective effects of magnesium valproate in type 2 diabetes mellitu | en_US |
| dc.type | Faculty Papers | en_US |
| Appears in Collections: | Faculty Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0129.pdf | IPFP0129 | 4.45 MB | Adobe PDF |  View/Open |
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