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http://10.1.7.192:80/jspui/handle/123456789/5321| Title: | Cardioprotective effects of magnesium valproate in type 2 diabetes mellitu |
| Authors: | Raghunathan, Suchi |
| Keywords: | IPFP0129 hyperglycaemia |
| Issue Date: | 2014 |
| Publisher: | Elsevier |
| Series/Report no.: | IPFP0129; |
| Abstract: | Wehaveevaluatedtheeffectofmagnesiumvalproate(210mg/kg/day,p.o.)intype2diabetesinduced cardiovascularcomplicationsinducedbystreptozotocin(STZ,90mg/kg,i.p.)inneonatalwistarrats.Various biochemical,cardiovascularandhemodynamicparametersweremeasuredattheendof8weeksof treatment.STZproducedsignificanthyperglycaemia,hypoinsulinemiaanddyslipidemia,whichwas preventedbymagnesiumvalproatetreatment.STZproducedincreaseinCreatinineKinase,C-reactive proteinandlactatedehydrogenaselevelsandtreatmentwithmagnesiumvalproateproducedreductionin these levels.STZproducedincreaseincardiacandLVhypertrophyindex,LV/RVratio,LVcollagendeposition andLVcardiomyocytediameterwhichweredecreasedbymagnesiumvalproatetreatment.Magnesium valproatealsopreventedSTZinducedhemodynamicalterationsandoxidativestress.Theseresultswere further supportedbyhistopathologicalstudiesinwhichmagnesiumvalproateshowedmarkedreductionin fibrosisandcardiac fiber disarray.Inconclusion,ourdatasuggeststhatmagnesiumvalproateisbeneficial as ananti-diabeticagentintype-2diabetesmellitusandalsopreventsitscardiaccomplications. |
| Description: | European Journal of Pharmacology 728 (2014) 128–134 |
| URI: | http://hdl.handle.net/123456789/5321 |
| Appears in Collections: | Faculty Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0129.pdf | IPFP0129 | 4.45 MB | Adobe PDF |  View/Open |
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