IR @ Nirma University
Keeping in tune the global developments we are creating an institutional repository using DSpace Software (Digital Library Software). We are archiving institutional knowledge like, faculty papers, theses, and dissertations in PDF format at DSpace. Students can access this digital information anywhere in the campus.
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http://10.1.7.192:80/jspui/handle/123456789/5330| Title: | Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors |
| Authors: | Patel, Bhumika |
| Keywords: | Dipeptidyl peptidase-4 Glucagon like peptide (GLP)-1 Non-peptidomimetics Diabetes |
| Issue Date: | 2014 |
| Publisher: | Elsevier |
| Series/Report no.: | IPFP0138; |
| Abstract: | Dipeptidyl peptidase-4 (DPP-4) is one of the widely explored novel targets for Type 2 diabetes mellitus (T2DM) currently. Research has been focused on the strategy to preserve the endogenous glucagon like peptide (GLP)-1 activity by inhibiting the DPP-4 action. The DPP-4 inhibitors are weight neutral, well tolerated and give better glycaemic control over a longer duration of time compared to existing conventional therapies. The journey of DPP-4 inhibitors in the market started from the launch of sitagliptin in 2006 to latest drug teneligliptin in 2012. This review is mainly focusing on the recent medicinal aspects and advancements in the designing of DPP-4 inhibitors with the therapeutic potential of DPP-4 as a target to convey more clarity in the diffused data. Peptidomimetics |
| Description: | European Journal of Medicinal Chemistry 74 (2014) 574e605 |
| URI: | http://hdl.handle.net/123456789/5330 |
| Appears in Collections: | Faculty Papers |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0138.pdf | IPFP0138 | 4.45 MB | Adobe PDF |  View/Open |
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