Cytogenetic studies in females with spontaneous multiple abortions

Abstract

AIM: This study was conducted to determine the contribution of chromosomal abnormalities in multiple abortions by means of karyotypic analysis and data mining. MATERIALS & METHODS: A total of 10 female individuals were enrolled in the study. Three of these female suffered with three spontaneous abortions, other three with five, six and eight spontaneous abortions each, respectively and four with unknown no. of spontaneous abortions. Chromosomal analysis from short-term cultured peripheral blood lymphocytes was performed according to the standard cytogenetic methods using GTG banding techniques. Data mining was done and reports were prepared using Dr. Borgaonkar website from year 1969-2008 (www.wiley.com/legacy/products/subject/life/borgaonkar) RESULT: Abnormal karyotype was found in two females with translocation t(4;8) and 9qh+, other eight female were found to be having normal karyotype. CONCLUSION: The results indicated that chromosomal abnormalities can play a role in some cases of multiple abortions. Cytogenetic analysis could be valuable for these females when clinical data fail to identify the cause.