Differential Scanning Calorimetry as a tool to establish formation of Lipid Nanoparticles (NLC and SLN)

Abstract

This study was carried out to assess impact of addition a liquid lipid on the crystallinity of the product and their pharmaceutical implication. The formation of NLC/SLN with GMS and OA was investigated by DSC. Protection of loaded drug in a physically stable formulation is the major advantage NLC/SLN provides which is lacking with other colloidal systems such as liposomes. DSC had been employed to assess physical nature of formulations. Physical state in form of solid is necessary for NLC/SLN lipid matrix. DSC studies had revealed that all formulations possess melting point over 40ºC confirms solid state at room temperature. Shift in melting events in NLC was due to the interaction of solid lipid with the oil and the drug or due to the nanometric size range of the formulation which had a huge surface area per volume.