Neuropharmacological actions of Celastrus Paniculatus Wills

Abstract

Alzheimer’s disease is a geriatric disorder characterised by amnesia and dementia. The pathology involves β-amyloid plaque formation, Tau hyper phosphorylation, Decrease in Acetylcholine availability, Free radical generation and Oxidative Stress. The current available treatment includes Acetylcholinesterase inhibitors and NMDA Receptor Antagonists. Attention Deficit Hyperactivity Disorder (ADHD) is a paediatric disorder which is finding its prominence in adolescents and the adults. The pathology links ADHD to imbalance in the neurotransmitters, Genetic links to Dopamine Transporter Genes, Brain injury, Prenatal and Perinatal exposure to pollutants like Lead, mercury, polychlorinated biphenyls, etc. The available treatments include Stimulant and Non- Stimulant medications. Ayurveda has classified Celastrus paniculatus oil as nootropic agent. The oil contains alkaloids, polyunsaturated fatty acids (PUFAs), carbohydrates, steroids and saponins which have properties may have neuroprotective effects. Purpose: 1. To evaluate neuropharmacological activity of Celastrus paniculatus in Alzheimer’s disease (AD). 2. To evaluate neuropharmacological activity of Celastrus paniculatus in Attention Deficit Hyperactivity Disorder (ADHD). 3. To investigate the mechanism of action of Celastrus paniculatus for AD. 4. To investigate the mechanism of action of Celastrus paniculatus for ADHD