Consequence of Wax Property on Drug Release Behavior of Oxcarbazepine Modified Release Granules

Abstract

Now a day’s various types of oral controlled release formulations have been developed to improve the efficacy of drugs as well as to increase patient compliance. Waxy materials are one of the materials to control the drug release from the formulations. Modified release granules of oxcarbazepine were prepared using three different waxes. Amount of wax and type of wax were selected as independent variables and drug release from the modified release granules at 2, 6 and 12 h were selected as dependent variables. Ideal drug release profile was generated using pharmacokinetic parameters of oxcarbazepine. Batch G4 was selected as best batch because it showed lowest sum of square of residue. SEM study of optimized batch of modified release granules shows that the drug particles are coated by glyceryl monostearate. The drug release from the modified release granules followed anomalous diffusion. The modified release granules were remained stable during stability study. The modified release granules can be a promising drug delivery for epilepsy.