Synthesis and Cell line study of Pyrazole Substituted Coumarin Derivatives

Abstract

Pyrazole substituted coumarin derivatives were synthesised via multi-component reaction namely 3-(4-substituted phenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde containing 4-hydroxy-2H-chromen-2-one and 4-methyl-2-oxo-2H-chromen-7-yl acetate by conventional synthetic route. The structure of the synthesised compounds was characterized by FTIR, Mass, 1H NMR spectral analysis. The synthesized compounds were screened for anticancer activity against the Lung cancer cell line (NCIH-522 cell line) using anticancer drug doxorubicin as a standard. Cell line studies revealed that compound 2-amino-4-(3-(4-chloro phenyl)-1-phenyl- 1H-pyrazol-4-yl)- 5-oxo-4, 5-dihydropyrano[3,2-c] chromene-3-carbonitrile found to be active against the lung cancer cell line as compared to doxorubicin.