Evaluation of Molecular Subtypes in Breast Cancer Patients and Its Correlation with Other Clinical Attributes and Treatment in Ahmedabad Region of India and Determination of Stress Levels in University Faculty

Abstract

Background and Purpose: Breast cancer is the most common cancer and second to lung cancer a cause of death around the world in Women. It is the most common malignancy in women in Developed countries, and about 12-15% of breast cancer occurs in the age between 20-34 years. The term BREAST CANCER refers to ‘Malignant tumor’ that begins from the cells of breast. And if severity occurs than it also spreads to other parts of the body. Breast cancer basically starting from breast tissue which is made up of glands responsible for milk production known as Lobules and also the ducts which connects lobules to nipple. And other parts of Breast is made up of Fatty tissue, Connective tissue and Lymphatic tissue. As per the data mentioned in 2013, an estimated 2,32,340 new cases of invasive breast cancer will be diagnosed among women and as well as 64,640 additional cases of in situ breast cancer has identified and approx. 39,500 women’s are estimated to die from breast cancer. Breast cancer estimates about 26% of all the new cancer cases will diagnosed in 2014 as compared to all other cancer. Methodology: A single centric retrospective study was carried out to examine Breast cancer patients and their correlation with treatment according to the molecular subtypes. The study was done at HCG Cancer Centre, Ahmedabad from the period between 5th December to 5th March. Only Females were included in the study .Female breast cancer patients undergoing Surgery/Chemotherapy/Radiotherapy/Combination of these therapies were also included in the study. Women having more than one cancer including breast cancer excluded from the study There are different parameters which was included in the study such as Molecular subtypes, Tumor Grade, Tumor metastasis, Lymph node involvement, Age at diagnosis, Cancer stage, Treatment, BMI. Case record form was included in the study separately for each patient to collect data from their respective files. Results: The study which has been done regarding with the breast cancer including 100 patients to our inclusion criteria and mainly those undergoing Surgery/Radiotherapy/Chemotherapy of these therapies. Women’s who have had more than one cancer was not included in this project. This Study of Breast cancer shows that Molecular subtypes is one of the leading factor for breast cancer prognosis and wecorrelates each of parameter with the molecular subtype of breast cancers with the clinical attributes, treatment modality and survival of patients and study indicates that Luminal A subtype is one of the most significant and common type of molecular subtype observed in Breast cancer study When we talk about BMI than most of the patients observed overweight i.e. 42% were observed in the study. From the data it has been observed that Age group is also one of the prevalent factor took place in breast cancer study and result concluded that 50-59 age group patients are more prone to breast cancer and about 34% of the cases were observed in the study.As we talk about surgery than it has been observed that 87 patients have undergone surgery and most patients have had MRM treatment and mostly surgeries were observed in Luminal A subtype i.e. 38%. From the data it has been observed that Surgery+ Chemotherapy+ Supportive treatment is one of the preferred treatment in breast cancer and most of the cases observed i.e 23% in Luminal A subtype. As we talk about severity of tumor than from the study it has been observed that around 19% cases were observed mostly in Luminal A subtype breast cancer and mostly BIRADS V category was common in Luminal A subtype breast cancer.Conclusion: It has been observed in the study that most of the patients are prone to breast cancer were from Luminal A subtype and thus 8% patients have breast metastasis in both Luminal A and Luminal B subtype of breast cancer. Age , BMI is one of the most prominent factor for breast cancer concluded from the study. At the end Chi square test is one of the liable test to prove which was the significant correlated factor observed in the breast cancer study and thus gives the data about prevalence of breast cancer with other parameters from the study.