Dissolution Enhancement of Sertraline HCI Using Solid Dispersion and S-Senedds: A Comparative Study

Abstract

Aim of the present study was to compare the dissolution rate of poorly water soluble drug Sertarline HCl by two approaches, solid dispersion and lipid based solid self-nanoemulsifying drug delivery system (S-SNEDDS) loaded tablets. Solid dispersion was prepared by kneading method using β-cyclodextrin as carrier for inclusion complex. For SNEDDS, preliminary solubility studies were carried out and ternary phase diagrams were constructed using Glycerol triacetate, Tween 80 and PEG 200. A 23 full factorial design was employed to optimise the effects of levels of oil, surfactant and cosurfactant on physicochemical responses % dissolution efficiency, globule size in nm and self-emulsification time in seconds). The optimized SNEDDS was adsorbed on microcrystalline cellulose (MCC) without affecting the nanoemulsifying ability of SNEDDS. In vitro drug release studies were performed in 0.05 Macetate buffer (pH 4.5). .The prepared inclusion complex was characterised in the liquid state by phase solubility study and SNEDDS was characterised for viscosity, refractive index, globule size and zeta potential. Differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) confirmed the compatibility of drug to polymer as no interaction was found and supported decreased crystallinity and increase in amorphous portion of the drug. Both of the formulations showed increase in the drug release compared to drug whereas S-SNEDDS showed significantly higher drug release than solid dispersion that may be due to its smaller globule size and surface charge. Thus lipid based S-SNEDDS appears to be a promising approach to enhance the dissolution rate of Sertraline HCl.