Design and Synthesis of Heterocyclic Molecules as Anti- Inflammatory Agents

Abstract

COX-2 inhibitors have been shown to interact with gastrointestinal, renal, andcardiovascular systems. They could delay ulcer healing,compromise the glomerular filtration rate, and may cause peripheral oedema and hypertension. They also cause bleeding and could promote a prothrombotic state and explain the observed increased cardiovascular risk. Finally ischemic preconditioning mechanism .Thus structural modifications are required and to get these structural modification there are so many new strategies and new methods were developed and one of the main significant change is to convert the free carboxylic group of NSAIDs into various acid derivatives.These changes lead to more selectivity and having less toxicity. In this study according molecular docking studies of designed compounds were done using cebyl for Mefenamic acid. Synthesis using DCC/DMAP,HATU/DIPEA,Pyridine/POCl3 coupling using different primary amines coupling was done. In-vivo screening of compounds with are JSAMA, JSNAP,JS_35DCA showed maximum inhibition.