Cytokine Profiling of Plasmodium Infection in Population of Two Different Regions

Abstract

Cytokine profiling has been carried out to see the different immune response in the Ahmedabad and Nadiad population. The levels of circulating cytokines depends on many factors including disease severity and the level of immune challenge. The ability of the immune system to establish a precise balance between Th1 and Th2 responses can be crucial to guarantee effective clearance of the pathogen without excessive damage to the tissues. In this study we measured the levels of TNF-α and IL-10 in the plasma of patients suffering from malaria. IL-10 levels were found to be high in the malaria infected individuals having high parasitic load exception was found in P. falciparum infected sample. There was a positive correlation between IL-10 and TNF-α levels in the plasma of malaria patients. Our study suggests with increase in parasite density IL-10 expression go up in contrary it down-regulates TNF-α expression. Clinical outcome of the disease is a consequence of the complex interaction between the pathogen and the host and survival of pathogen largely depends on the type of cytokine (Th1/Th2) being produced by host’s immune cells on encounter.