DESIGN, DEVELOPMENT AND IN- VITRO EVALUATION OF COMPRESSION COATING v/s CONVENTIONAL COATING TECHNIQUES

Abstract

Regulatory authorities have been strict about the criteria of coating like its appearance, quality, colour fading, etc., so to avoid such shortcomings of conventional coating a novel approach have been discovered which is compression coating technique. The objective of this work is to investigate the feasibility and similarity of compression coating in comparison with conventional technique through various parameters. Compression coated tablet containing API in the core was formulated with a dry powder coat containing swelling agent using direct compression. The percentage weight ratio and the coating level were selected as critical process parameters (CPPs), whereas critical quality attributes (CQAs) were hardness, cumulative percentage drug release at 8 hour for controlled release compression coated tablet. Similarly, conventional coated tablets were also prepared giving a profile at 8 hour drug release. The results obtained were on the basis of the drug release which were satisfactory and hence can be concluded that for controlled release compression coating can be used. On the other hand, another experiment was executed to check the practicability for same. The coating was carried out for immediate release dosage form consisting of film forming polymer and super disintegrant. The critical quality attributes (CQAs) for immediate release tablet was the disintegration time. The results were compared to check the effectiveness of compression coated tablet. From the study conducted it was concluded that the immediaterelease profile can be accomplished with solvent less coating approach. Hence, compression coating is achievable and can overcome various defects that are faced by the conventional coating method. Other advantages over conventional coating can be incorporation of two incompatible drugs, attaining synergistic effect, targeted release, cost effective, etc. Due to its various advantages, this technique can be explored further.