IR @ Nirma University
Keeping in tune the global developments we are creating an institutional repository using DSpace Software (Digital Library Software). We are archiving institutional knowledge like, faculty papers, theses, and dissertations in PDF format at DSpace. Students can access this digital information anywhere in the campus.
Please use this identifier to cite or link to this item:
http://10.1.7.192:80/jspui/handle/123456789/8303Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Pawar, N. | - |
| dc.contributor.author | Gadgoli, C. | - |
| dc.contributor.author | Kamble, M. | - |
| dc.contributor.author | Panchal, S. | - |
| dc.date.accessioned | 2019-04-04T08:31:01Z | - |
| dc.date.available | 2019-04-04T08:31:01Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.uri | http://10.1.7.192:80/jspui/handle/123456789/8303 | - |
| dc.description | Pharmacology Online, 2016 Vol. 2: 163-174 | en_US |
| dc.description.abstract | Nyctanthesarbour-tristis(NAT),Oleaceae,isoneofthemostpopularmedicinalplantinAyurvedicandHomeopathicSystemsofIndianmedicine.NATflowerspossessmultiplepharmacologicalactivitiesanditscalyxisreportedtopossesscarotenoidswhichisresponsibleforrenderingallitsmedicinalproperties.TherationalebehindpresentstudyinvolvesNATflowersconsumptionforvariousmedicinalutilitiesandcommonlyasafoodingredientwithoutanyinformationaboutitsassociatedrisks.Thereforeforthepresentstudy,OECDguidelineno.407of28dayssub-acutetoxicitystudywasfollowedcriticallybyusing48wistarratsofeithersex(24maleand24female).Thedoserangeof250,500and750mg/kgbodyweightofNATextractwasselectedbasedonpreliminarydosedeterminationexperimentsandadministeredbyoralgavagetotherespectivegroups.NATcalyxextracttreatmentinducedsignificantalterationsinessentialhaematologicalparameterslikeRBCs,MCV,MCHCandPlateletsinatleastonetreatedgrouptherebyindicatingitstoxiceffectonhaematologicalsystemaftertheexposurefor28days.ALTlevelsweresignificantlyincreasedbyNATtreatmentsuggestingitspossiblehepatotoxicnatureafterexposurefor28days.Mortalityoffouranimalsfromtreatedgroupswasrecordedattheintermediatestageofthestudy.Hence,cautionshouldbeexercisedwithNATcalyxtreatmentattheconcentrationof250mg/kgbwandabove,whenrequiredtobeconsumedfortheperiodgreaterthan14days. | en_US |
| dc.publisher | PharmacologyOnLine | en_US |
| dc.relation.ispartofseries | IPFP0311; | - |
| dc.subject | Nyctanthesarbour-tristis | en_US |
| dc.subject | Sub-acutetoxicity | en_US |
| dc.subject | Carotenoids | en_US |
| dc.subject | OECDno.407 | en_US |
| dc.subject | OECDno.425 | en_US |
| dc.title | 28-Days Sub-acute Toxicity Profile of Ethanolicextract of Nyctanthes arbor-tristis Calyx in Rats | en_US |
| dc.type | Faculty Papers | en_US |
| Appears in Collections: | Faculty Papers | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IPFP0311.pdf | IPFP0311 | 1.03 MB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.