DEVELOPMENT OF CHITOSAN BASED MODIFIED POLYMER FOR PHARMACEUTICAL APPLICATIONS”

Abstract

Development of Chitosan Based Modified Polymer for Pharmaceutical Applications: The aim of the present research was to fabricate and develop new polymeric combination for Pharmaceutical application. Chitosan is a natural and iopolymer. It has an in built property like non-toxic, Biocompatible, biodegradable atural cationic polymer acknowledge for its immunogenicity, chitosan is well known for its ntimicrobial effect and some research proved its activity as a wound healing polymer. VA is chemically versatile polymer and it is potential agent for various pharmaceutical nd biomedical applications. PVA is water soluble and excellent biocompatible polymer. It as admirable physical properties like mucoadhesive and swelling which make it ppropriate for diverse drug delivery application. PVP is a water soluble polymer so sily inds with polar molecules. It has an admirable wetting properties and it was form a film. t has good coating properties and use as an additive. As per literature review Chitosan-PVA and Chitosan- PVP two different combination was studied and there was found an admirable property in various pharmaceutical as well as biomedical pplications like tissue engineering, hydrogels, Nano formulations etc. Present study was done using physical approach and it has advantageous over chemical modification like higher yield, no any chemical residual, comparatively less toxic. Polymeric fabrication was carried out using freeze drying technique. From literature review, three polymers were selected. The solubility study was carried out in acetic acid and water. Preliminary trials were carried out by varying the ratio of polymers. Full factorial design was used selected for screening. Two significant factors were found to have significant effect, freeze drying time and water adsorption. For further optimization 22 full factorial design was applied. Design space was studied. FTIR, DSC and TGA were used to characterise fabricated polymeric combination. Microbial study was done to check for antimicrobial effect. It was concluded from the microbial study that the developed polymeric ombination inhibited growth of E. coli and S. aureus. So, the fabricated polymeric combination has found biomedical application.