Formulation Development and Characterization of Irinotecan Liposome

Abstract

In 90’s, Paul Ehrlich (A Germany scientist), declared the term “magic bullet,” means chemical carriers which possess the property of choosiness in killing damaged cells without any effect on the living cells. [1] Many of the approaches which are depending on the number of chemical and physical properties were adopted To improve the specificity through drug delivery technology,. Liposomes is very small bilayer of round shape which are formed from natural phospho lipids, other lipids and cholesterol. Due to their hydrophilic and hydrophobic character and, size of liposomes are favorable mechanism for drug delivery system. Characteristics of liposomes may vary with formulation of lipid, particle size, zeta potential and the method of manufacturing. In addition, the main component of bilayer components like phospholipids and cholesterol regulates the ‘fluidity’ or ‘rigidity’ and the zeta of the bilayer of liposome. Un-saturated phospholipids origin from super natural sources like soybean or egg phosphatidyl choline are far more penetrable and less steady bilayers, whereas the saturated phospho lipids, like dipalmitoylphosphatidylcholine, HSPC, DSPG, DSPC form a intact, rather resistant bilayer Structure