Pharmacodynamic and pharmacokinetic study of Novel Nanoparticles of Irinotecal Hydrochloride in Fibrosarcoma

Abstract

Sarcomas are a rare and diverse group of dangerous tumors that emerge embryologically from mesenchyma in connective tissues. Fibrosarcoma can be treated with the use of radiotherapy in combination with chemotherapy. The treatment is still challenging due to a number of unwanted side effects, increased costs, and unknown risk factors. Irinotecan is a highly effective anti-cancer agent but reported to have poor bioavaibility, large dose is require to obtained good therapeutic effect. The way of improving solubility and side effects irinotecan can be formulated into nanoparticles. Therefore, aim of present study is to develop drug entrapped gelatin nanoparticulate system for targeted drug delivery to specific site of action, improve drug stability, retention time and with no or less side effect.