Design and synthesis of the Chalcone Derivatives as Anti- Cancer Agents

Abstract

As per the statistics by the World Health Organization the highest mortality rate is observed in the cancer in all the types of population inhabitation either for emergent or the developed countries. The data suggest that cancer is the principal cause of decease in populace after cardiovascular disorder internationally, which is accountable for an anticipated 96 lack persons because of cancer in 2018 while worldwide this data hovers around every single individual out of 6 dies due to cancer. GLOBOCAN (Indian Institute of Medical Research) 2018 suggests that in India every year 11 lakh cases of cancer are arising and out of that 7 lack morbid patients are recorded. In India the highest cases reported are of breast cancer and 9.58% of the total population comprising both the genders have the risk developing cancer before 75 years. The overall deaths which result in 2018 in India is around 7 lacks. Oral and pulmonary cancer are responsible for the 25% people who loss their lives in concerened with male while in case of female the major threat is the breast cancer as well as oral cavity. 1.1 CANCER Cancer is not only a bodily conditions but it is a physiological alterations take place in order to develop the mass of undifferentiated cells which are found additional in the body and hamper the normal body functions. In broad terms the cancers can be sub-divided on the basis of cell type, tissue or origin. Cancer should not be understood as one abnormality but it is the collection of the events that occur through the abnormal cells that develop by bypassing the normal cell death signals. Normal cells present in the body have some distinct mechanism that chooses whether the cell will live or will be destroyed in the organs like liver or spleen but the cancerous cell have become independent of the signals that make them die and maintain their existence.