Implications of Innate Immunity with Age-Associated Neurodegenerative Disease, Employing Model Organism Caenorhabditis Elegans

Abstract

Parkinson’s disease (PD) is a polygenic ailment missing entire therapy. Understanding the total system of commencement and development of this disease had been really challenging; however, development has been made in the direction of decoding the contribution of genetic elements related to this disorder. Immune reaction may additionally make contributions in worsening mind inflammatory response and the presence of antibodies in opposition to neuronal antigen found in neurological sicknesses (some of them being pathogenic), deepens the involvement of the immune mechanism in neurodegenerative disorder. As a result an acute neuro-inflammatory reaction is favourable to the CNS, minimizing the harm by triggering the innate immune system. Considering these aspect we have tried to implicate innate immunity in context of Parkinson’s disease by using transgenic C. elegans as a model system. By Computational literature mining we have screened 21 genes. Amongst all, 6 genes were showing homology above 90% and were considered for further study and experiments. Out of which 3 genes were showing promising results till now. These genes are egl- 30, lgg-1, ubh-1 which might be putative gene targets and modulator in context of Parkinson’s disease and immune system. After identification of these targets functional genomics studies are done in this aspect. Their pathway analysis will be studied involving all cell signalling pathways modulating immunity and age associated PD.These genes will be further tested with experimental compound to test their pharmacologicaleffects on various endpoints of the disease