Formulation Development Optimization and Characterization of Antiemetic Lozenges of Meclizine Hydrochloride for Treatment of Motion Sickness

Abstract

The plethora described in this work emphasizes on the development of lozenges of meclizine hydrochloride for the treatment of motion sickness. Motion sickness is a very common disorder and is still neglected and not much emphasis has been done on the treatment of motion sickness. This work comprises of lozenge formulation of a BCS class 2 drug by enhancing its solubility by making the solid dispersion of the same. Solubility of meclizine was enhanced by solid dispersion by fusion method and excipients were finalized by trial batches. Optimum excipients were finalized by batches and were finalized. Design expert software was used and factorial design was applied. Parameters like DT, Drug release and drug permeation were evaluated and came to the conclusion that lozenges of meclizine hydrochloride showed good drug release and almost 70% of drug gets releases in 30 mins making drug available directly into the systemic circulation and thus increasing its onset of action. Also this type of formulation is not available in market increasing its novelty.