Lipid-Based Nano-Delivery for Oral Administration of Atazanavir: Design, Optimization and Characterization

Abstract

In the world there are millions of people suffering from the HIV positive. There are various medications are available for the HIV, which includes the various antiretroviral treatment having the safety. Antiretroviral are given orally so also there is possibility of the drug interaction. Lipid carries used to solubilize the very poorly soluble drug. Lipids with the short chain, long chain medium chain were used as oil phase. The Atazavair is the class four drug having the very solubility so the purpose of this study is to check the solubility of the drug Atazanavir sulfate with the various lipids. This lipid carrier was formulated an evaluated with the particle size, zeta potential, drug loading. Materials and methods: - Various types of oils and surfactant, co-surfactant was used for the solubility study like capmul, transcutol, labrazol. The phase diagram was used for the study.