Fabrication and Characterization of Crisaborole Lipid Nano Particulate System for The Treatment of Atopic Dermatitis

Abstract

Dermatitis is known as skin inflammation having symptoms like dry, swollen, and red skin. Generally long contact with a surfactant, heavy metals, detergent, etc causes dermatitis. Dermatitis is a very common skin disorder. The objective of this study was to formulate and characterize Crisaborole loaded Nanostructured lipid carriers (NLCs). Crisaborole is an anti-inflammatory agent That acts as a phosphodiester-4 inhibitor and use for the treatment of atopic dermatitis. Crisaborole loaded NLCs will be incorporated in gel because of ease in topical administration. Crisaborole NLCs were due to its small size and lipidic nature showing better penetration Precirol ATO 5 as a solid lipid and Glyceryl monooleate as a liquid lipid was selected based on the highest solubility of Crisaborole. While Tween 20 was selected as a surfactant was selected based On minimum solubility of crisaborole and T20 ability stabilization. Hot melt homogenization technique used to formulate NLCs and effects of different factors like surfactant type and its concentration, co-surfactant type, and its concentration, effect of homogenization speed was studied on the formulation characteristics. NLCs were characterized by Particle size, Entrapment Efficiency. The particle size of Crisaborole loaded NLCs was 100nm to 150nm; which is optimum for topical delivery and observing PDI-0.251. %EE is also 82% that shows good entrapment of Crisaborole.