Development and Evaluation of Novel Cosmeceutical Formulation for The Treatment of Skin Disorder

Abstract

Affecting the one third part of the world, skin disease are found very common. Most of the people tend to ignore the earlier symptoms till it worsens. Later when the disease progresses it affects the people’s Quality of Life (QOL). Rosacea is the clinical manifestation with unknown pathophysiology. Rosacea is further classified into four subtypes. The current research focuses on the subtype I. There are many approaches been carried to treat out the disorder therapeutically. Cosmeceutical approaches are trending and they enhance the aesthetic appeal of an individual. Developing a novel formulation while exploring new excipients was the major objective of the current research work. Gel creams are an innovative concept which can deal with the problems with the prevailing marketed therapeutic formulations. Gel creams provide the quicker absorption, enhance the hydration and can camouflage the erythemea caused by rosacea. In this ongoing research work two actives are used Metronidazole and Liquid extract with plant origin developed from White biotechnology. Formulation was developed using the basic aspects of the topical formulation and keeping the objective as the centre point. Two different formulas are prepared with these two actives. The entire process of formulation is disunited into three phases. Formula has gel as an external phase and the cream /emulsion as the internal phase. Selection of the excipients is done keeping the critical quality attributes of a topical formulation to develop a quality formulation. Excipients like Gelling agent, Waxes, Ratio of Emulsifiers and Emollients were studied deeply and evaluated. Selection of the excipients was done qualitatively and quantitatively. Physical attributes, Viscosity, Appearance, Spreadability, pH and After-feel were some parameters that were evaluated. Based on the evaluations and the recurrent trials with enhancing quality with each trial two formulas were finalised as the conclusion having the good physical stability.