Identification of Novel Biomarkers for Gestational Preeclampsia

Abstract

Preeclampsia is a complex disease whose clinical evaluation varies with wide vaiety of unpredictable clinical manifestations and adverse effects with complicated health outcomes for mother and foetus during and post pregnancy. Though surprisingly, prevention and prediction of gestational preeclampsia with hypertensive abormalities has proven to be a core challenge for professional workers/physician. Multifarious strategies are developed to predict and diagnose the disease at early age of gestation to prevent unwanted complications during pregnancy and at the time of delivery. Still, most of the studies remains unconclusive constant attempt are going on through systematic research and reviews by conductuing surveys to understand detailed pathophysiology and pathogenesis of occurrence of preeclampsia and related complications during gestation. Since, no reliable tests results are proven to be succssful for predicting preeclampsia, heath care professionals gather their core interest in diagnosis of preeclampsia by relevent indications and risk factors with biomarkers. In this review, basic concept of gestational compliactions is discussed with considering preeclampsia during pregnancy. Detailed analysis on occureence of disease at early stage of development with it’s pathophysiology is discussed. Elaborated knowledge on diagnostic and preventive mathods are discussed with various management therapies depending on the severity of the disease in a patient. Lastly, novel biomarkers to predict gestational preeclampsia is focussed upon to extrafoliate and modify exsisting strategies.