Development and Optimization of Luliconazole Loaded Nanostructure Lipid Carrier System for The Treatment of Fungal Infection

Abstract

This study aimed to formulate and evaluate luliconazole-loaded nanostructured lipid carrier for topical applications. This NLC prepared by a hot high shear homogenization method. Compritol 888 ATO as solid lipid, alpha-tocopherol as liquid lipid, tween80 use as a surfactant, and capriole 90 used as a co-surfactant. The particle size of luliconazole NLC between 49nm to 150nm it’s optimum for topical nano-drug delivery. luliconazole NLC microscopy studies showed that all particles in a spherical shape. These results indicate that the studied luliconazole-NLC formulation with skin targeting may be a promising carrier for the topical delivery of luliconazole. PDI of luliconazole observed 0.351, so it is in good rang of PDI. Luliconazole NLC has excellent stability compared to the marketed formulation of luliconazole.