Development and Optimization of Metformin Hydrochloride Sustained Release Tablets

Abstract

The objective of this study was to compare natural and synthetic polymers to develop metformin hydrochloride sustained release matrix tablet. Polyox WSR-301, HPMC K100M, Eudragit L100 were taken as synthetic polymers while Guar gum, Xanthan gum and sodium alginate were taken as natural polymers. Matrix tablets containing 250mg metformin hydrochloride and polymers in different ratio (1:0.5, 1:1, 1:2) were produced by direct compression and optimized using pre-compression and post-compression parameters such as angle of repose, Carr‟s index, Hauner‟s ratio, hardness, friability, weight variation, drug content and in-vitro drug release. From the results obtained by in-vitro drug release profile, it was concluded that Polyox WSR-301, HPMC K100M, Eudragit L100 offered desired results at low ratios of 1:0.5, 1:1 and 1:0.5 respectively, while Xanthan gum and sodium alginate at ratio of 1:2 and guar gum failed to offer required drug release as per USP i.e 85% drug release in 12 hrs