Nano Emulsion Gel in Transdermal Drug Delivery System

Abstract

Transdermal drug delivery is one of the best medical preparation devices and give lots of advantages than another dosage form. TDDS is developed by corporating different method about the dose of penetration of drugs by the skin of the patient.1 Transdermal drug delivery is non-trespassing method in which dose penetrates through the different layer of the skin & imparts desired systemic or local pharmacological effects on the body. Conventional transdermal drug delivery shows its some problem in penetration of the drug over this method. To overcome this problem some of the novel penetration enhancement methods include iontophoresis, electroporation, ultrasound, microneedles, nano gels and most recently the use of nanocarriers like polymeric micellar nanoparticles, nanospheres, liposomes, nano emulsions & dendrimers are being employed.2 The body exterior is protection by the skin, interact with environmental condition and prevent the straight effect of the internal part of the body with surrounding.3 As nanocarrier can easily pass through the stratum corneum and require no device for application it has a great future for drug delivery and diagnosis of various diseases. The present project is an attempt to overview conventional transdermal drug delivery, its formulations and formulation strategies using nano emulsion to dimities the permeation problem. The evaluation of drug delivery and different approaches of nano emulsion gel with its application and future implication is also discussed. In the Transdermal drug delivery (TDDS) drug is penetrated through the skin. So, physicochemical properties are important for the drug material. Transdermal drug delivery is divided in two types, one is reservoir and another one is matrix system. TDDS have benefits like consistence, removal of first pass, large area for skin to deliver a drug, fast dosing capacity. There is prevention to drug pass through across the layer caused by stratum Therefore, by nano gel emulsion we can improve the deprived drug transference in trans-dermal drug delivery so the drug can also penetrate by no any distress in the SC (stratum corneum)