Review on Effect of Herbal Drugs in treatment of Alzhiemer's Disease

Abstract

Alzheimer’s disease is a common cause of dementia the distinctive features includes ‘neurofibrillary tangles’ and ‘amyloid beta plaques’ in the intracellular atmosphere, ‘neuronal death’ and ‘loss of synapses’, all of which contribute to cognitive decline in a progressive manner. In 2019 Alzheimer’s disease International (ADI) gauges that there are over 50 million individuals living with dementia worldwide, a figure set to increment to 152 million by 2050. Current therapies induces FDA approved 5 drug works on Acetylcholine inhibitors and NMDA antagonist to treat its symptoms that demonstrated modest benefits, but likely does not alters disease progression. However, there is an urgent need for the development of new lead inhibitor compounds with least toxicity. A vast studies have been so far carried on preclinical & clinical studies among this natural plants showed Cholinesterase Inhibitors, Modification of monoamines, Anti-amyloid aggregates, Antioxidant and Phosphodiesterase Inhibitors (Flavonoids, Alkaloids, Saponins, Lignans, Coumarins and essential oil). This review highlight the pharmacological basis of Tinospora Cordifolia and Garlic to control oxidation stress, amyloid beta plaques and protective effects in the treatment of AD, which will benefit to the biological scientists in understanding and exploring the new in-site of natural chemical compound in combating Alzheimer’s disease.