Solubility Enhancers and Enhancement Techniques

Abstract

In this thesis we are going to talk about mainly two techniques used to increase solubility of two different poorly H2O soluble drugs. First technique is liquisolid compact technique which is a promising technique in enhancing solubility. It was tested on drug Etoricoxib. This drug is almost insoluble in H2O. PEG. MCC, SSG and Aerosil were used to prepare compacts. To measure concentration of drug, UV spectroscopy was used. To measure purity, melting point was measured. To check interaction between drug and other materials, techniques like FTIR and DSC were used. 6 different formulations were prepared and were numbered as F1 to F6. Altering carrier to coating ingredients were used to prepare the formulation. Solubility and release studies were carried out for compact to compare the formulation. The result were in favour of compacts and also best results were given by F4 and F5 and F5 having almost 97% solubility. The usage of appropriate solvent for the drug curcumin to increase its solubility, stability and bioavailability was done. NDES (Natural Deep Eutectic) are used for this purpose. Curcumin has almost nil solubility in H2O. Also it has very less stability. So the solvent is tested for extraction, stability and solubility. Stimulated gastrointestinal fluids were used to study release of drug with solvent. For extraction turmeric powder was used. UV spectroscopy was used to measure conc. of drug. Quantum computational chemistry was also performed to check the basis of increase in solubility using appropriate instruments and methods. The drug in solvent showed favourable results in terms of extraction, stability and solubility than the pure drug. Ch. cl. and glycl. components shown best results for solubility and the ration was 1:1 and also solubility increased as temperature was increased. So this solvent was used as in all processes of drug starting from extraction to dissolution aid.