Docking Study of Marketed Anti-Malarials on New Malaria Targets

Abstract

Malaria is a very crusial disease as per the WHO (world health organisation). Malaria is one of the most pivotal parasitic diseases in humans and the malarial parasite transmission in above 100 countries of a population of five million people. Malaria is primarily happen by Genus Plasmodium protozoan parasites. But much of the transmission occurs by female anopheles mosquito. The other infecting species are a variety of hosts, including reptiles, birds, rodents and primates. There are several other medications commercially available but Proguanil is a malaria-fighting prophylactic agent. The malarial parasite such as Plasmodium falciparum and P.vivex ceases. It replicates in the blood and inhibits a reductase of the enzyme dihydrofolate. Describe the common types of new antimalarial objectives in this article. There's several drugs available on the malaria market in this form of study but prefer some new drugs that have been tested on the targets. There's many different targets available but DHODH and DHFR showed strong potential and that's why we have preferred these targets for a docking study. Here we should take out a molecular docking study of the different malaria drugs and also know about the docking software. In the docking softwere we are going to make a whole docking study of the receptor and ligand. So in that docking I had used drugs which is from the different classes. These types of the drugs will informed us for the binding site of the drug. Thus I used to make a different coloumn and the content of the drugs for the binding. Anti malarial drugs will be docked and then described it binding site of the content. There are plenty of binding sites with the molecule which we will dock and from that which sites have a good potential to bind with the drugs and show a good interaction. In docking study we can know about the potency of the drug or their binding property with the drug. There are certain targets which will bind with the drugs and show some results.