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http://10.1.7.192:80/jspui/handle/123456789/9784Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Rathod, Gaurav P. | - |
| dc.date.accessioned | 2021-02-12T10:42:09Z | - |
| dc.date.available | 2021-02-12T10:42:09Z | - |
| dc.date.issued | 2020-05 | - |
| dc.identifier.uri | http://10.1.7.192:80/jspui/handle/123456789/9784 | - |
| dc.description | Guided by Prof. Manjunath Ghate | en_US |
| dc.description.abstract | Monoacyl glycerol lipase (MAGL) enzyme belongs to Serine Hydrolase superfamily. MAGL play a role in catabolism of 2-AG (2-Arachidonyl glycerol). 2-AG is a neurotransmitter in endocannabinoid system. Which have some physiological actions. MAGL gives the Arachidonic acid and Glycerol by degrading 2-AG. This Arachidonic acid producing pro-inflammatory agents like prostaglandins, throxanes. So, the major role of MAGL inhibitors as anti-inflammatory, antinociceptive and anti-cancer agents. Recent studies suggest that the repeated administration of MAGL inhibitor will lost its activity and produced cross tolerance to cannabinoid receptor (CB1). In this review we discuss about the Biochemical and Physiological role of MAGL inhibitors, and various scaffolds which are discovered as potent for inhibition of MAGL | en_US |
| dc.publisher | Institute of Pharmacy, Nirma University, A'bad | en_US |
| dc.relation.ispartofseries | PPR01028; | - |
| dc.subject | PPR01028 | en_US |
| dc.subject | B. Pharm Project Report | en_US |
| dc.subject | Medicinal Chemistry | en_US |
| dc.subject | Monoacyl glycerol lipase (MAGL) | en_US |
| dc.subject | neurotransmitter | en_US |
| dc.subject | cannabinoid receptor | en_US |
| dc.title | A Review on MAGL Inhibitor | en_US |
| dc.type | Project Report | en_US |
| Appears in Collections: | B. Pharm Project Reports | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PPR01028.pdf | PPR01028 | 1.02 MB | Adobe PDF |  View/Open |
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